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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K3
All Species:
20.91
Human Site:
Y245
Identified Species:
38.33
UniProt:
P46734
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46734
NP_002747.2
347
39318
Y245
P
E
L
N
Q
K
G
Y
N
V
K
S
D
V
W
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
G281
M
F
G
C
Q
V
E
G
D
A
A
E
T
P
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_546666
347
39324
Y245
P
E
L
N
Q
K
G
Y
N
V
K
S
D
V
W
Cat
Felis silvestris
Mouse
Mus musculus
O09110
347
39278
Y245
P
E
L
N
Q
K
G
Y
N
V
K
S
D
V
W
Rat
Rattus norvegicus
Q4KSH7
419
47517
Y299
P
D
P
T
K
P
D
Y
D
I
R
A
D
V
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511595
352
40240
Y250
P
E
L
N
Q
K
G
Y
N
V
K
S
D
V
W
Chicken
Gallus gallus
Q90891
398
44059
G287
P
V
V
D
G
A
E
G
E
S
H
S
V
S
P
Frog
Xenopus laevis
Q07192
446
50082
Y331
P
S
A
S
R
Q
G
Y
D
V
R
S
D
V
W
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
Q258
R
I
N
P
E
T
N
Q
K
G
Y
N
V
K
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477162
334
38176
V233
Q
Y
D
I
R
S
D
V
W
S
L
G
I
G
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
R249
S
S
D
K
Y
D
V
R
S
D
V
W
S
L
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
I251
T
Y
D
Y
S
S
D
I
W
S
L
G
M
S
V
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
V543
P
D
R
A
T
Y
T
V
Q
S
D
I
W
S
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
30.7
N.A.
99.1
N.A.
96.5
37.2
N.A.
89.7
30.3
42.1
75.3
N.A.
57
N.A.
37.7
N.A.
Protein Similarity:
100
47
N.A.
99.7
N.A.
98.8
56.7
N.A.
93.1
48.7
58
84.4
N.A.
72.9
N.A.
55.6
N.A.
P-Site Identity:
100
6.6
N.A.
100
N.A.
100
33.3
N.A.
100
13.3
53.3
0
N.A.
0
N.A.
0
N.A.
P-Site Similarity:
100
13.3
N.A.
100
N.A.
100
73.3
N.A.
100
26.6
86.6
13.3
N.A.
6.6
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.7
23.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.2
35.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
8
0
0
0
8
8
8
0
0
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
16
24
8
0
8
24
0
24
8
8
0
47
0
0
% D
% Glu:
0
31
0
0
8
0
16
0
8
0
0
8
0
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
8
0
39
16
0
8
0
16
0
8
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
0
8
0
8
0
0
0
8
0
8
0
8
8
0
0
% I
% Lys:
0
0
0
8
8
31
0
0
8
0
31
0
0
8
0
% K
% Leu:
0
0
31
0
0
0
0
0
0
0
16
0
0
8
8
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% M
% Asn:
0
0
8
31
0
0
8
0
31
0
0
8
0
0
0
% N
% Pro:
62
0
8
8
0
8
0
0
0
0
0
0
0
8
16
% P
% Gln:
8
0
0
0
39
8
0
8
8
0
0
0
0
0
0
% Q
% Arg:
8
0
8
0
16
0
0
8
0
0
16
0
0
0
0
% R
% Ser:
8
16
0
8
8
16
0
0
8
31
0
47
8
24
8
% S
% Thr:
8
0
0
8
8
8
8
0
0
0
0
0
8
0
0
% T
% Val:
0
8
8
0
0
8
8
16
0
39
8
0
16
47
8
% V
% Trp:
0
0
0
0
0
0
0
0
16
0
0
8
8
0
47
% W
% Tyr:
0
16
0
8
8
8
0
47
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _